AB0659 EXTREMELY LOW FREQUENCY OF CHRONIC HEPATITIS B INFECTION IN SYSTEMIC LUPUS ERYTHEMATOSUS

Background There are few studies evaluating the frequency of chronic hepatitis B virus (HBV) infection in systemic lupus erythematosus (SLE) patients (1). Objectives Aim this study is to determine HBV seroprevalence SLE and compare it with normal population patient control groups (rheumatoid arthritis spondyloarthritis). Methods serology tests [hepatitis surface antigen (HBsAg), antibody (HBsAb), core (HBcAb)] performed during diagnosis 278 group [consist 125 rhomatoid (RA) spondhyloarthritis (SpA)] were analyzed retrospectively between 2005-2022 two different centers. Patients responding 2019 ACR/EULAR criteria included. characteristics compared those groups. The categorical data presented as numbers (in percent). chi-square test or Fisher’s exact was used analyze variables. We 95% confidence intervals (95% CI) for rate each variable; CI which did not overlap considered statistically significant. Statistical significance p<0.05. Results HBsAg positive 2/278 (0.7%) patients, 6/125 (4.8%) RA 9/125 (7.2%) SpA patients. positivity lower than national analysis [%4, (218/5960), %4,57, p=0,008] (p=0,019) (P=0,003) (2,3). HBcAb (%15) significantly both (%30.6) (%42.7) (Table 1). Analysis clinical outcomes showed that less oral ulceration (5/38 vs 57/210, p=0.067) skin lesions (18/38 140/208, p=0.018) occured negative no relationship other findings positivity. older (51±10 42±13, p<0.001). Table 1. Hepatitis P SLE-RA SLE-SpA Normal (TURHEP) SLE-normal (%0.7) (%4,8) 0,019 (%7,2) 0,003 218/5960 (%4) 0,008 41/273 44/103 (%42,7) <0,001 37/121 (%30,6) <0.001 1670/5460 HBsAb 107/278 (%38.5) 62/117 (%53) 0.008 51/122 (%41,8) 0,43 1746/5460 (%31,9) 0.023 77/273 (%28.2) 26/103 (%25,2) 0,33 25/121 (%20,7) 0,11 463/5460 (%8,4) 30/273 (%11) 30/103 (%29,1) 0,01 1212/5460 (%22,2) 11/273 14/103 (%13,6) 12/121 (%9,9) 0,02 251/5459 (%4,6) 0.659 Conclusion inflammatory disease subgroups such RA. Lower seroprevelance also diseases (SpA RA), maybe due specific protective mechanisms pathogenesis (like association familial mediterrenian fever pestilence). This mechanism can be explained high interferon levels To properly understand these mechanisims we need more prospective molecular studies. References [1]X Chen, L Hong, W Zhang et al. Virus Infection Rate Distribution Chinese Systemic Lupus Erythematosus Patients. Med Sci Monit. 2015; 21: 1955–1959. [2]N Tozun, O Ozdogan, Y Çakaloglu, . Seroprevalence C infections risk factors Turkey: a field work TURHEP study. Clin Microbiol Infect. 2015 Nov;21(11):1020-6. [3]M Toy, FO Önder, T Wörmann, Age- andregion-specifichepatitis prevalence Turkey estimated using generalized linear mixed models: systematic review. BMC Infect Dis. 2011 Dec 12;11:337. Disclosure Interests None declared